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Article Type

Original Study

Abstract

Background (Introduction): Melatoninhas a widespread antioxidantactivitiythat protects the gastrointestinalmucosa from oxidative damageandpotentiates healing of duodenalulcer.Omeprazole is also reported tobeclearly effective in this healingprocess.The aim of study: is to evaluatethe role of melatonin and omeprazolein the treatment of duodenal ulcereither alone or in a combinedtherapy.Subjects & Methods: 36 adultmale persons were included in thisstudy. They were divided into 4 groups; group I (9 control volunteers),group II (9 patients sufferingfromchronic duodenal ulcer and receivingmelatonin alone), group III (9patientssuffering from chronic duodenalulcer and receiving omeprazolealone)& group IV (9 patients sufferingfrom chronic duodenal ulcer andreceivinga combination of melatoninandomeprazole). Endoscopic biopsieswere taken for histological & immunohistochemicalstudies. Results : Complete healing of theduodenal mucosa was observed after8 weeks of treatment in Group II,after6 weeks of treatment in Group < br />IIIand after 4 weeks of treatment inGroup < br />IV. Before treatment, immu- nohistochemical study of sections ofulcerated duodenum showed strongpositive immune reaction for COX-2enzyme. With treatment, the immunereaction was moderate then becamemild or weak after complete healing.Conclusion: it could be concludedthat combination therapy of both melatoninand omeprazole is preferableintreatment of chronic duodenal ulceras melatonin could acceleratethehealing effect of omeprazole ,shortenthe duration of treatmentandminimize its side effects.

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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