Article Type
Original Study
Abstract
Panobinostat is a new histone deacetylaseinhibitor approved fortreatmentof advanced multiple myeloma.In this study we compare itseffectswith doxorubicin which is alreadyused for trans-arterial chemoembolizationof hepatocellular carcinoma. Methods: anti-proliferativeand pro-apoptotic effects of panobinostatand doxorubicin are tested bymeasuringcell viability, P53, pd1 expressionand cell cycle analysis inHepG2cells cultured in suitable mediaand incubated with both drugs for24hours. Results:Panobinostat wasfoundto highly significantly induce apoptosis via increasing expressionof both P53 and pd1 and decreasecell viability and mitosis more thandoxorubicin. Conclusion: These resultssuggest that panobinostat maybea potent alternative to doxorubicinfortreatment of hepatocellular carcinoma.
Recommended Citation
Elhakam Elmetwaly, Neimat Abd; Younis Youssef, Mona; Abd Elhameed Mohammad, Amal; Mohammad Abd Elrahman, Karawan; and Hanem Mohammad Ali Elbanna, Farida
(2015)
"COMPARING ANTIPROLIFERATIVE AND PROAPOPTOTIC EFFECTS OF THE PAN-DEACETYLASE INHIBITOR PANOBINOSTAT WITH DOXORUBICIN ON HEPG2 HEPATOCELLULAR CARCINOMA CELL LINE,"
Mansoura Medical Journal: Vol. 44
:
Iss.
1
, Article 6.
Available at:
https://doi.org/10.21608/mjmu.2015.124268
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