Article Type
Original Study
Abstract
Dyslipidemia is one of the major risk factors for ischemic heart diseases.Vegetable oils as flaxseed and corn oils draw the attention because theyowe many health benefits as antioxidant and anti-inflammatory. Objectives:This work aimed to study the possible role of flaxseed and corn oils in preventionor attenuation of acute myocardial infarction in male rats fed a highfatdiet. Methods:64 adult male rats were divided into 4 groups: group standard diet fed rats,(2) high fat fed group < br /> (3) high fat diet and supplementedwith flaxseed oil and and for medicinal purposes for hyperlipidemia.Also, they may be useful adjuncts to reduce alterationsin liver metabolism and the risk of cardiovasculardisease. There are many studies demonstratedthat ingestion of polyunsaturated fattyacids(PUFA) present in vegetable oils, is inverselyproportional to the incidence of cardiovasculardiseaseby reducing plasma triglyceride levelsandcholesterol (Barcelo-Coblijn& Murphy, 2009;Tzanget al., 2009).Omega 3 (PUFAs) are basicallyfound in fish, particularly in anchovies, tunaandsalmon. Flaxseed is considered an importantsourceof PUFA, which is obtained from Linumusitatissimumplants (Linaceae family), croppedmainlyin China, Argentina, Brazil, India, Canadaand Turkey (Sammour, 1999).(1)control(4)high fat diet and supplemented withcorn oil group. After 8 weeks myocardial infarction was induced by isoprenalineinjection for 2 consecutive days. ECG, serum lipid profile and serumCK-MBwere assessed. Results:Flaxseedoil supplementation produce significantincrease in QRS amplitude, shortening of QTc interval and less STelevation.Flaxseed oil improved the lipid profile and decreased the serumlevelof CK-MB. Whereas corn oil supplementation showed, a significant decreasein ST segment elevation but insignificant change in QRS amplitude,andQTc interval. Corn oil significantly decrease CK-MB but less than flaxseedoil. Conclusion:Flaxseed and corn oils exhibit cardioprotective effectsinattenuation of acute myocardial infarction in rats fed a high fat diet. Flaxseedoil has more cardioprotective effects may be attributed to its highercontentof omega 3 fatty acids.
Recommended Citation
Abdel-Halim, Nehal; Ghalwash, Mohammad; Sarhan, Mohammad; and Borae, Mohammad
(2016)
"Effect of flaxseed and corn oils on acute myocardial infarction in high fat diet fed rat,"
Mansoura Medical Journal: Vol. 45
:
Iss.
1
, Article 4.
Available at:
https://doi.org/10.21608/mjmu.2016.123883
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This work is licensed under a Creative Commons Attribution 4.0 International License.
