Serum level of Interleukin-33 and relation to disease activity in Juvenile Idiopathic Arthritis

Zeinab Zeid, Rheumatology and Immunology unit, Internal Medicine Department, Faculty of Medicine, Mansoura University, EgyptFollow
Ehab Eltoraby, Rheumatology and Immunology unit, Internal Medicine Department, Faculty of Medicine, Mansoura University, EgyptFollow
Adel Abdelsalam, Rheumatology and Immunology unit, Internal Medicine Department, Faculty of Medicine, Mansoura University, EgyptFollow
Youssef Mosaad, Clinical pathology Department, Faculty of Medicine, Mansoura University, EgyptFollow
Samar Tharwat, Rheumatology and Immunology unit, Internal Medicine Department, Faculty of Medicine, Mansoura University, EgyptFollow

Corresponding Author

Zeid, Zeinab

Subject Area

Immunology

Article Type

Original Study

Abstract

Abstract Background The pathogenesis of juvenile idiopathic arthritis (JIA) is not fully understood. So, this study was conducted to investigate clinical usefulness of serum IL-33 levels as an indicator of disease activity in JIA. Methods This cross-sectional study was conducted on 45 JIA patients. All patients were subjected to detailed history taking, full clinical examination with emphasis on pattern and distribution of articular and extra-articular involvement. Juvenile arthritis disease activity score (JADAS28) was assessed. Venous blood (10 ml) was collected to assess routine laboratory investigations in addition to IL-33. Results Most of patients had sudden arthritis onset (64.4%) and (95.6%) had progressive course. Most of patients (64.4%) had general sites of distribution. 88.9% had emotional aggravation factor, while 86.7% had medication and movement as relieving factors. Only 8.9% of patients’ diseases are controlled, 46.7% had relapse, and 6.7% stopped treatment. 66.7% of patients had good response and 33.3% had poor response. JIA patients had a significantly higher serum IL-33 levels compared to IL-33 serum in the control group (p=0.008). There were significant positive correlation between IL-33 with duration of disease (p=0.002, r=0.612), DAS28CRP (p < 0.001, r=0.705) and DAS28ESR (p=0.001, r=0.667), However, serum IL- 33 levels did not significantly correlate with the levels of serum CRP or ESR. Conclusions JIA patients have significantly elevated IL-33 serum concentrations and that considerably correlated with clinical, laboratory and activity parameters of disease suggesting that it could be a valuable marker of JIA disease activity.

Recommended Citation

Zeid, Zeinab; Eltoraby, Ehab; Abdelsalam, Adel; Mosaad, Youssef; and Tharwat, Samar (2022) "Serum level of Interleukin-33 and relation to disease activity in Juvenile Idiopathic Arthritis," Mansoura Medical Journal: Vol. 51 : Iss. 2 , Article 4.
Available at: https://doi.org/10.21608/mjmu.2022.121843.1054