Wheezy and Cough Asthma Phenotypes in a cohort of Egyptian Children: Clinical features and CCR3 T51C Gene Polymorphism

Magdy Mohamed Zedan, Professor of Pediatrics, Pediatric Department, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt.Follow
Mai Magdy Kera, Resident of Pediatrics, Zifta general hospital, Ministry of health, EgyptFollow
Eman Omar Khashaba, Assistant Professor of Occupational Health and Industrial Medicine, Public Health and Community Medicine Department, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt
Mona El Wassefy, Assistant Professor of Clinical Pathology, Clinical Pathology Department, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Amal Mohamed Osman, Assistant Professor of Pediatrics, Pediatric Department, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Corresponding Author

Mai Magdy Kera

Subject Area

Immunology

Article Type

Original Study

Abstract

Background: Asthma is a heterogenous disease with variable characteristic phenotypes. Correlating clinical asthma phenotypes with the underlying genotypes could pave the way for development of tailored asthma medications. Objective: The purpose of this study was to describe the clinical features of wheezy and cough asthma phenotypes and to assess the frequency of CCR3T51C gene polymorphism among Egyptian asthmatic children. Methods: A group of 60 Egyptian asthmatic children (40 wheezy phenotype and 20 cough phenotype) together with 100 controls were enrolled and analyzed for the genotypes of CCR3 T51C polymorphisms using PCR-RFLP. Serum IgE levels were determined by ELISA technique. Results: Regarding the clinical characteristics, associated allergic rhinitis and atopic dermatitis were found to be significantly higher among wheezy phenotype compared to cough phenotype. Also, most of the patients with wheezy phenotype had moderate to severe asthma while most of the patients with cough phenotype had mild asthma. Regarding the frequency of CCR3 T51C genotypes, the TT homozygote genotype was the most frequent genotype among cases and controls. However, no statistically significant differences were found between the two clinical phenotypes. Conclusion: In our studied population, wheezy asthma phenotype was characterized by higher frequency of associated allergic march and increased asthma severity. Yet, our results deny the value of CCR3T51C genetic polymorphism as a genetic marker for differentiating between wheezy and cough asthma phenotypes.

Recommended Citation

Zedan, Magdy Mohamed; Kera, Mai Magdy; Khashaba, Eman Omar; El Wassefy, Mona; and Osman, Amal Mohamed (2023) "Wheezy and Cough Asthma Phenotypes in a cohort of Egyptian Children: Clinical features and CCR3 T51C Gene Polymorphism," Mansoura Medical Journal: Vol. 52 : Iss. 1 , Article 6.
Available at: https://doi.org/10.58775/2735-3990.1379