•  
  •  
 

Corresponding Author

Sara Khashaba

Subject Area

Dermatology

Article Type

Original Study

Abstract

Background: Vitiligo is the most common depigmenting skin disorder. Destruction of melanocytes result in depigmented skin lesions. Pathogenesis is not fully understood and mostly is multifactorial. However, the autoimmune theory is the most widely accepted one. The interaction between genetic, environmental, biochemical and immunologic factors contribute to the disease. Cytokines have an important role in development of the disease and its progression. Aim of the work: The aim of the present study is to measure the blood levels of C-X-C motif chemokine ligand 10 (CXCL10) in vitiligo and to correlate it with disease activity and severity. Methods: This is a case-control study enrolled 60 vitiligo patients (30 had active vitiligo and 30 had stable vitiligo) and 30 healthy age- and sex-matched controls. Vitiligo Extent Score (VES) was calculated. CXCL10 was measured in venous blood samples using ELISA. Results: CXCL10 levels were significantly higher among vitiligo patients compared to controls (P

Conclusions: Serum levels of CXCL10 were significantly higher in vitiligo patients compared to healthy controls. Furthermore, patients with active vitiligo had higher levels of CXCL10 compared to stable group. Moreover, patients with higher VES had higher CXCL10 serum levels.

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Download

Share

COinS