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Background Significant evidence does exist regarding the significant role of inflammation in the development of atherosclerosis. Lipoprotein phospholipase A2 is a phospholipase A2 enzyme (Lp-PLA2) which is predominantly produced by macrophages and lymphocytes in atherosclerotic plaque. Increased Lp-PLA2 concentrations are significantly linked to atherosclerosis-related diseases which include cardiovascular diseases and ischaemic strokes. Aim This study was conducted to assess the role of serum level of Lp-PLA2 in cerebral atherosclerosis. Methods This prospective cross-sectional case-control study enrolled 100 patients aged 60 years old or more with acute ischaemic stroke (AIS). Using the TOAST classification, patients were divided into case group "atherosclerotic” and control group" non atherosclerotic "including cardioembolism, small vessel occlusion, stroke of other determined etiology and stroke of undetermined etiology. Results The median LP2A was significantly higher in atherosclerotic cases as compared to non-atherosclerotic cases (132.5 versus 49.75, respectively). Significant negative association was found between GCS and L2PA in addition to positive correlation between L2PA and the following; NIHSS at admission, NIHSS at discharge and mRS at discharge. A statistically significant relationship was revealed between L2PA and Hypercholesterolemia among the atherosclerotic group (p

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Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.