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Background: Platelets play a role in atherosclerosis, inflammation, and thrombosis. Prothrombotic events, activation, aggregation, and adhesion are all increased by elevated mean platelet volume (MPV) and platelet distribution width (PDW) levels; high low-density lipoprotein (LDL) raises the risk of cardiovascular disease. Aims: Investigate the association between platelet indices, lipid profile, stroke severity, and outcome in patients with acute ischemic stroke. ‎ Subjects and methods: A prospective case-control study involved 100 acute ischemic stroke patients and 100 controls from Mansoura University Hospitals. Patients underwent neurological assessments, including the National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS), and Alberta Stroke Program Early CT Score (ASPECTS). Laboratory investigations included the complete blood count, platelet indices, and lipid profiles. Results: The study involved a population of 63% males and 37% females. The mean of (MPV) and platelet lymphocyte ratio (PLR) were significantly higher in cases than in controls. However, the PDW was significantly lower in cases than in controls. The lipid profile showed significant differences in MPV, PLR, and LDL levels. The mean MPV in anterior circulation stroke (ACS) was 9.3 ± 1.25, while in posterior circulation stroke (PCS) it was 10.2 ± 0.9. The mortality rate in cases was 28%, with a significant difference between cases who died and those who survived regarding MPV and PLR. A significant negative correlation was found between the MPV, PDW, and mortality rate, while a positive correlation was found between the mortality rate and PLR and LDL. Conclusion: Higher platelet indices, LDL, and total cholesterol (TC) in stroke patients had a major effect on patient mortality and stroke severity.

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Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.