Subject Area


Article Type

Original Study


Background: Acne vulgaris (AV) is a common, chronic, inflammatory lesion of the pilosebaceous unit. Oxidative stress played an essential role with regard to pathogenesis of many dermatological conditions. Aim: The aim of the present study is to assess Complete blood count (CBC) parameters and monocyte to high -density lipoprotein ratio (MHR) as indicator of inflammation, assess Ischaemia-modified albumin (IMA) as indicator of oxidative stress in acne vulgaris patients and to examine their relation to acne vulgaris severity. Methods: This was a case-control study included 48 acne vulgaris patients and 40 healthy individuals age and sex-matched controls. Global acne grading scale (GAGS) was calculated. Complete blood count & differential leukocytic count was done using hematology auto analyzer five-part differential. High density lipoprotein (HDL) was estimated, MHR was calculated and serum IMA was measured. Results: serum IMA was significantly higher in acne vulgaris patients in comparison with control group. While MHR level did not differ significantly between case and controls. IMA revealed positive correlation with GAGS. Conclusions: This result suggests that IMA accompanied by oxidative stress could have an essential role in AV pathogenesis and it is associated with disease severity.

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Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.