Subject Area

Chest medicine

Article Type

Original Study


Background: Exposure to environmental tobacco smoke (ETS) is associated with several medical diseases especially allergy, but little is known about the effects of cigarette smoking on allergen immunotherapy response. Aim: This study aims to explore any association between cigarette smoking and response to allergen immunotherapy in patients with allergic airway disorders. Patients and methods: The study was conducted on patients with allergic airway disorders who received subcutaneous immunotherapy. All patients were assessed as regard smoking history including pack-year index and dependence, symptoms and medication scores. Patients’ demographic and clinical data were collected. A statistical analysis was then performed. Results: A total of 54 patients were enrolled 48 males (88.9%) and 6 females (11.1%), with mean age of 30.6 ±12 years. Coincidence of Allergic rhinitis & bronchial asthma was the most frequent in 23 patients (42.6%). Non-smoker patients were the most frequent representing 63%, followed by current smokers in 29.6%. Symptom and medication scores in current smokers were highly significant better after Allergen Immunotherapy (AIT) (P =0.001, 0.005 respectively), ex-smoker showed significant improvement as regard symptoms score (P =0.05), but with no significant improvement as regard medication score (P =0.06). Among non-smokers, there was a highly significant improvement in both symptom and medication scores after AIT (P =

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Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.