Subject Area


Article Type

Original Study


Background: Optical coherence tomography (OCT) and OCT-angiography (OCT-A) permit quantification of retinal layer atrophy relevant to multiple sclerosis (MS) progression. Methods: We conducted this case-control study to assess of the changes in OCT and OCTA measures in relation to the duration of MS and the expanded disability status scale (EDSS). A total of 70 MS patients compared to 35 healthy controls were enrolled. Results: According to OCT findings, there was a significantly lower mean value of retinal nerve fiber layer thickness (RNFL) and ganglion cell complex (GCC) in the MS patients group compared to the control group with p1.5 exhibited significantly lower average values of RNFL and GCC. The mean RNFL values were 82.29±17.21 compared to 98.31±9.17, and the mean GCC values were 82.57±4.95 in contrast to 95.02±7.25. The patients' group had a significantly lower mean value of all OCT-A measurements than the control group (p1.5 had a statistically significant lower mean value of whole image, parafovea, superior and inferior hemispheres compared with cases with no a disability EDSS ≤1.5. Conclusion: We found that MS patients' retinas had thinner retinal layers and less dense blood vessels. We highlighted the important clinical relationship that exists between vascular density, EDSS, and retinal layer thickness. This suggests that OCT and angio-OCT may be useful markers of MS patients' impairment and disease progression.

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Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.