Role of Serum Ferritin and D-Dimer on Short Term Outcome in Acute Ischemic Stroke

Nourhan Ahmed Galal Sadek, Neurology Department, Faculty of medicine, Mansoura University, EgyptFollow
Mohammed Mahmoud Abbas Ali, Neurology Department, Faculty of medicine, Mansoura University, Egypt
Yousra Mahmoud Amin Tera, Clinical Pathology Department, Faculty of medicine, Mansoura University, Egypt
Mohamed Abd-El-Salam Mohamed Ali, Neurology Department, Faculty of medicine, Mansoura University, Egypt

Subject Area

Neuropsychiatry

Article Type

Original Study

Abstract

Background: Acute ischemic stroke (AIS) has been considered as a main reason of death globally. Currently, intervention could significantly enhance outcomes and reduce disability. Studies have been conducted to determine the factors that may have a role in the context of AIS prognosis formulation. Prognostic indicators, that has gained great clinical interest recently, are serum ferritin and D-dimer (DD). Aim: The aim of the current study was to assess the relation between serum levels of both ferritin and DD and severity of AIS at time of presentation and its relationship with the short-term outcome of patients. Methods: The present study was an observational prospective study with analytic component that was carried out on 100 patients. All patients were subjected to measuring severity of stroke using National Institute of Health Stroke Scale (NIHSS) score at time of admission and 5 days later for short term outcome and measuring of serum level of both D-dimer and ferritin on admission. Size of infarction on CT was determined by multiplying area of infarction by number of CT slices and slice thickness. Ischemic infarction size > 1.5 cm was categorized as large vessel infarction. Results: There was statistically significant positive correlation between NIHSS initial and NIHSS at follow up with serum ferritin and D-Dimer. There was statistically significant correlation between serum ferritin level and CT brain results as regard small and large vessel infarction with higher median ferritin is detected among cases with large vessel than small vessel disease. There was statistically significant relation between D-dimer level and CT brain results (p

Recommended Citation

Sadek, Nourhan Ahmed Galal; Ali, Mohammed Mahmoud Abbas; Tera, Yousra Mahmoud Amin; and Ali, Mohamed Abd-El-Salam Mohamed (2023) "Role of Serum Ferritin and D-Dimer on Short Term Outcome in Acute Ischemic Stroke," Mansoura Medical Journal: Vol. 53 : Iss. 1 , Article 3.
Available at: https://doi.org/10.58775/2735-3990.1392