Study of Serum bilirubin in relation to stable chronic coronary artery disease severity and outcome after percutaneous intervention

Khaled E Mahfouz, M.B.B.CH., MS cardiovascular medicine, Mansoura University, Mansoura, EgyptFollow
Ahmed W Suliman, Cardiology department, Faculty of Medicine, Mansoura University, Mansoura. Egypt
Mahmoud A Youssef, Cardiology department, Faculty of Medicine, Mansoura University, Mansoura. Egypt.
Adel M Osman, Cardiology department, Faculty of Medicine, Mansoura University, Mansoura. Egypt.

Subject Area

Cardiology

Article Type

Original Study

Abstract

Background: Bilirubin is endogenous antioxidant and increased its physiological concentrations reduce severity of coronary artery disease with better prognosis after PCI. Objective: Assess serum bilirubin level in patients with stable chronic coronary artery disease and correlate it with the severity of this disease and outcome after PCI. Methods: Cross sectional prospective observational study included 203 Patient with stable chronic coronary artery disease divided into 2 groups according to bilirubin: group I ≤ 0.6mg/dl group II > 0.6 (up to 1.2) mg/dl 100 cases underwent elective coronary angiography and PCI with full clinical examination, laboratory tests: total serum bilirubin, creatinine, lipid profile, ECG, echocardiography, and follow up of MACCE after 6 months and 1 year. Results: A highly significant increase in SYNTAX score, total MAACE after 6 months especially heart failure also total MAACE after 12 months especially revascularization , heart failure and cerebrovascular stroke in cases with bilirubin ≤ 0.6mg/dl with higher incidence than other group with highly significant negative correlation between bilirubin and T wave abnormalities, heart failure and MACCE after 6 months, revascularization , heart failure (HF) , cerebrovascular stroke and MACCE after 12 months., also there was significant negative correlation between bilirubin and ST segment elevation, RWMA, SYNTAX score, MI after 6 months. Conclusion: serum bilirubin level in stable chronic coronary artery disease is correlated with SYNTAX score and severity of disease and could be used to predict incidence of MAACE after PCI.

Recommended Citation

Mahfouz, Khaled E; Suliman, Ahmed W; Youssef, Mahmoud A; and Osman, Adel M (2024) "Study of Serum bilirubin in relation to stable chronic coronary artery disease severity and outcome after percutaneous intervention," Mansoura Medical Journal: Vol. 53 : Iss. 1 , Article 9.
Available at: https://doi.org/10.58775/2735-3990.1408