Pathogenic Role of Angiopoietin-1 and -2 in Community-acquired pneumonia among a Cohort of Egyptian Children from Rural Areas of Delta Region

Magdy Mohamed Ebrahim Zedan, Professor of Pediatrics, Pulmonology, Allergy and Clinical Immunology unit, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Nashwa Khairat Abousamra, Professor of clinical pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Engy Osman Ahmed, Professor of Pediatrics, Pulmonology, Allergy and Clinical Immunology unit, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Asmaa Salah Ali Gebril, Department of Pediatrics, Faculty of Medicine, Mansoura University, Mansoura, EgyptFollow

Corresponding Author

asmaasalahgebril92@gmail.com

Subject Area

Chest medicine

Article Type

Original Study

Abstract

Background: Both an uncontrolled host response and the direct actions of pathogenic agents can be responsible for pneumonia-induced pulmonary hyperpermeability. Two well-known factors that contribute to angiogenesis and regulate inflammation and vascular leakage are angiopoietin-1 (Ang 1) and angiopoietin-2 (Ang 2). Aim: Assessment of Ang 1 and Ang 2 serum levels as indicators of the severity and phenotypes of community-acquired pneumonia (CAP). Subjects and methods: From September 2023 to February 2024, a case-control study was carried out at Mansoura University Children Hospital (MUCH) to assess the serum levels of Ang-1 and Ang-2 as indicators of the severity and phenotypes of communityacquired pneumonia. The study included 30 cases aged 2 months to 16 years admitted to MUCH from rural areas of Delta region diagnosed with community-acquired pneumonia using WHO diagnostic criteria and 30 healthy controls of matched age and sex. Clinical and laboratory data were used to categorize the 30 pneumonic cases into two groups: typical pneumonia (n = 24) and atypical pneumonia (n = 6). Results: Community-acquired pneumonia (CAP) cases had a male to female ratio of 1.3:1 with a median age of 3 years (0.17–16). The most prevalent symptoms among pneumonic cases were fever, cough, and difficulty of breathing (93.3%, 90%, and 76.7%, respectively). The most frequent complications among cases were pleural effusion and septicemia (56.7% and 30%, respectively). The most frequent radiologic finding among cases was parapneumonic effusion (56.7%), which was followed by lobar pneumonia (26.7%) and bronchopneumonia (23.3%). Cough was much more common in children with typical CAP (95.8%) than in those with atypical CAP (66.7%). Compared to children with typical CAP, children with atypical CAP used macrolides far more frequently. Although the pneumonic group's Ang-2 was substantially greater than the control group's (p-value = 0.02), there was no statistically significant difference in Ang-1 between the cases and healthy controls. Pneumonic cases complicated with septicemia had considerably higher levels of both Ang-1 and Ang-2 (p-value

Recommended Citation

Zedan, Magdy Mohamed Ebrahim; Abousamra, Nashwa Khairat; Ahmed, Engy Osman; and Gebril, Asmaa Salah Ali (2024) "Pathogenic Role of Angiopoietin-1 and -2 in Community-acquired pneumonia among a Cohort of Egyptian Children from Rural Areas of Delta Region," Mansoura Medical Journal: Vol. 53 : Iss. 3 , Article 3.
Available at: https://doi.org/10.58775/2735-3990.1428