•  
  •  
 

Subject Area

Nephrology

Article Type

Original Study

Abstract

Background While COVID-19 primarily manifests clinically as a respiratory disease, it can also impact other organs, such as the kidneys. Acute kidney injury (AKI) is frequently seen in hospital-admitted patients with COVID-19 and is linked to poorer outcomes. This research sought to explore the rate, contributing elements, and consequences of AKI in individuals with COVID-19. Methods Data from 236 COVID-19-infected patients hospitalized at wards and intensive care units (ICUs) dedicated to isolation between September 2020 and February 2021 were analyzed. Comparisons between patients with and without AKI were done using statistical tests as appropriate. Binary logistic regression analyses were performed at the univariable and multivariable levels to identify AKI risk factors. Survival data based on AKI status was analyzed using the Kaplan-Meier curve. Results Overall, 81 (34.3%) of 236 participants experienced AKI during their hospitalization. Hospitalized COVID-19 individuals with age > 64 years, Favipiravir use, vasopressors use, pH ≤7.4, HCO3 ≤19.2, and blood glucose >212 mg/dl have 2.4-, 2.5-, 2.4-, 3.4-, 3.2-, 2.9-times higher odds to exhibit AKI. A significantly lower survival probability was found in individuals with AKI than in non-AKI (log-rank χ2(2) = 41.187, p < .001). A shorter median survival time for patients with AKI compared with those without was also noticed (8 days [95% CI 7.132–8.868] versus 12 days [95% CI 10.910-13.090]). Conclusion AKI is not uncommonly encountered in patients with COVID-19 in the course of their hospitalization and is linked to increased mortality.

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Download

Share

COinS