Effect of Preoperative Stripsils Lozenges on Incidence of Post-extubation Sore Throat, Cough and Hoarseness after Endoscopic Retrograde Cholangiopancreatography Procedures: A Randomized Controlled Trial.

Tarek Habeeb Ramadan, Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Mansoura University, Mansoura, EgyptFollow
Waleed M R Elsarraf, Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Ahmed Refaat Abourezk, Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Mohamed Aly Eloraby, Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Corresponding Author

Tarek Habeeb Ramadan

Subject Area

Anaesthesia and Surgical Intensive Care

Article Type

Original Study

Abstract

Background Sore throats are frequently experienced by patients following upper endoscopy procedures such as endoscopic retrograde cholangiopancreatography (ERCP). Cough and hoarseness of voice are other related complications. Aim of the work The current study evaluated whether pre-procedural oral Strepsils lozenges administration could reduce sore throat incidence and severity following ERCP procedures. Methods Sixty patients posted for elective ERCP under general anesthesia (GA) with endotracheal intubation were evenly allocated in a random manner to receive Strepsils lozenges (S group) or identical-looking placebo tablets (C group) 45 minutes before the procedure. Results The Strepsils group experienced a significantly lower incidence of both early (1 hour) and late (24 hours) postoperative sore throat (POST) when compared to the control group (33.3% vs 73.3%, P=0.002) for early POST and (16.6% vs 43.3%, P=0.024) for late POST. Group S demonstrated significantly reduced sore throat severity versus Group C at 1h,6h,12h, and 24h (P=0.004, 0.004, 0.028, and 0.023, respectively) along with lower early cough incidence (P=0.02). No significant differences were reported regarding the incidence of late cough, hoarseness, or other procedure-related complications. Moreover, 83.3% of the Strepsils group were satisfied, while only 46.7% of the placebo group were satisfied (P=0.003). Conclusions Preoperative Strepsils lozenges offer a promising and simple preventive method for postoperative sore throat and cough especially in ERCP procedures.

Recommended Citation

Ramadan, Tarek Habeeb; Elsarraf, Waleed M R; Abourezk, Ahmed Refaat; and Eloraby, Mohamed Aly (2025) "Effect of Preoperative Stripsils Lozenges on Incidence of Post-extubation Sore Throat, Cough and Hoarseness after Endoscopic Retrograde Cholangiopancreatography Procedures: A Randomized Controlled Trial.," Mansoura Medical Journal: Vol. 54 : Iss. 2 , Article 3.
Available at: https://doi.org/10.58775/2735-3990.1450