Subject Area
Hepatology and GIT
Article Type
Review Article
Abstract
In children, hepatitis C virus (HCV) remains a serious health concern, especially those receiving cancer treatment, where repeated blood transfusions and immunosuppression significantly increase the risk of infection. The use of direct-acting antivirals (DAAs) represents a turning point in HCV management, delivering high cure rates with fewer side effects than previous therapies. In this review, we explore the latest insights into HCV epidemiology, transmission, and pathophysiology in pediatric patients, with particular attention to those facing malignancy. We will discuss the mechanisms of action, approved treatment regimens, and safety profiles of DAAs, focusing on combinations like sofosbuvir/ledipasvir in the oncology setting. The review also highlights clinical challenges, practical treatment considerations, and areas where further research is needed. Early screening and timely incorporation of antiviral therapy into cancer care pathways are essential steps toward improving long-term outcomes for this high-risk group.
Recommended Citation
Aboelfotoh, Ashrakat Galal; Mohamad, Ahmad Darwish; and Hassan, Ahmed Megahed
(2025)
"Direct-Acting Antivirals for Chronic Hepatitis C virus infection in Children with malignancy: A Review of Current Evidence and Clinical Insights,"
Mansoura Medical Journal: Vol. 54
:
Iss.
2
, Article 5.
Available at:
https://doi.org/10.58775/2735-3990.1448
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This work is licensed under a Creative Commons Attribution 4.0 International License.