Relationship Between Serum Micro-Rna 192 And 29c And Kidney Disease In Subjects With Type 2 Diabetes Mellitus

Amr Y. El Feky, Internal medicine department, Faculty of Medicine, Alexandria University, Alexandria, EgyptFollow
Talaat A. Abdelaaty, Internal medicine department, Faculty of Medicine, Alexandria University, Alexandria, Egypt
Azza A. Ismail, Internal medicine department, Faculty of Medicine, Alexandria University, Alexandria, Egypt
Rania M. Elsharkawy, Chemical Pathology department, Medical Research Institute, Alexandria University, Alexandria, Egypt
Mohamed F. Amara, Internal medicine department, Faculty of Medicine, Fayoum University, Fayoum, Egypt
Shimaa M. Elrahmany, Internal medicine department, Faculty of Medicine, Alexandria University, Alexandria, Egypt

Subject Area

Endocrinology

Article Type

Original Study

Abstract

Background Diabetic kidney disease (DKD) is a frequent and serious complication of type 2 diabetes mellitus (T2DM). This study aimed to assess the relationship between micro- RNA (miRNA)-192 and miRNA-29c expression and DKD in patients with T2DM. Patients and methods A case-control study was conducted with 160 participants: 40 T2DM patients with DKD, 40 T2DM patients without DKD, and 80 healthy controls. Plasma levels of miRNA-192 and miRNA-29c were quantified using quantitative reverse transcription PCR. Diagnostic accuracy was assessed via ROC curve analysis. Multivariate logistic regression identified predictors of DKD. Results Micro RNA-192 expression was significantly elevated while miRNA-29c expression was reduced in DKD patients. Multivariate regression analysis confirmed miRNA-192 as a positive predictor (OR = 3.19, p = 0.009) and miRNA-29c as negative predictor (OR = 0.04, p= 0.004) of DKD. The ROC curve analysis revealed that miRNA-192 had an AUC of 0.79 (65% sensitivity, 92.5% specificity), and miRNA-29c had an AUC of 0.71 (95% sensitivity, 57.5% specificity).Conclusion Both miRNA-192 and miRNA-29c show promise as biomarkers for DKD detection in patients with T2DM.

Recommended Citation

El Feky, Amr Y.; Abdelaaty, Talaat A.; Ismail, Azza A.; Elsharkawy, Rania M.; Amara, Mohamed F.; and Elrahmany, Shimaa M. (2025) "Relationship Between Serum Micro-Rna 192 And 29c And Kidney Disease In Subjects With Type 2 Diabetes Mellitus," Mansoura Medical Journal: Vol. 54 : Iss. 3 , Article 3.
Available at: https://doi.org/10.58775/2735-3990.1455