Could Angiopioetin-1 & Angiopioetin-2 be considered a predictor for community acquired pneumonia severity and phenotypes

Magdy Mohamed Zedan, Professor of Pediatrics, Professor of Pediatrics Allergy, Respiratory and Clinical Immunology Unit, Mansoura university children hospital, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Nashwa Abusamra, Professor of Clinical pathology, Professor of Clinical pathology, Clinical pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Engy Osman, Professor of Pediatrics, Professor of Pediatrics Allergy, Respiratory and Clinical Immunology Unit, Mansoura university children hospital, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Rania mohammed emad eldin Eldersy, Department of Pediatrics, Faculty of Medicine, Mansoura University, Mansoura, Egypt. Department of pediatrics , Sammanoud central hospital, Ministry of health, Egypt.Follow

Corresponding Author

Rania Mohammed Emad Eldin Eldersy

Subject Area

Chest medicine

Article Type

Original Study

Abstract

Background: Community-acquired pneumonia (CAP) is a major cause of morbidity and mortality worldwide and the role of biomarkers in pneumonia has been evaluated in many clinical areas. Angiopoietin-1 and Angiopoietin -2 are glycoproteins that play role in vascular development, angiogenesis, and permeability. Aim: To conduct a trial for phenotyping and endotyping of pneumonia using Angiopoietins-1 and Angiopoietin -2. Subjects and methods: This case-control study included 30 cases and 29 controls of matched age and sex. to investigate Angiopioetin-1 & -2 serum levels in both groups and then evaluated the possible association between serum Angiopoietin -1&-2 in different pneumonia phenotypes. Results: As regards cases, there were higher proportion of children aged from 3months-5 years diagnosed with typical CAP. Patient had a higher level of Angiopoietin-1\-2 than controls. There were high median levels of Angiopioetin-2 in cases with respiratory distress, and typical CAP cases had higher prevalence of wet cough. However, atypical CAP cases had a higher prevalence of wheezes. Children with typical CAP had a higher prevalence of complications while almost all atypical CAP cases hadn’t complications. Cases complicated with septicemia showed high levels of Ang-1 & Ang-2. In radiology, typical CAP cases had higher prevalence of para-pneumonic effusion, however, atypical CAP cases had higher prevalence of interstitial pneumonia. Conclusion: Typical CAP is more prevalent among young children and causes severe clinical characteristics, complication and radiological finding compared with atypical. Our results suggest that increased serum level of Ang-1 & Ang-2 goes with severe clinical presentation and with severe complications.

Recommended Citation

Zedan, Magdy Mohamed; Abusamra, Nashwa; Osman, Engy; and Eldersy, Rania mohammed emad eldin (2025) "Could Angiopioetin-1 & Angiopioetin-2 be considered a predictor for community acquired pneumonia severity and phenotypes," Mansoura Medical Journal: Vol. 54 : Iss. 4 , Article 7.
Available at: https://doi.org/10.58775/2735-3990.1466