ASSOCIATION OF URIC ACID INDEX AND CARDIOVASCULAR RISK IN EGYPTIAN PATIENTS WITH TYPE 2 DIABETES

Reem Fathallah, Department of Internal Medicine (Diabetes, Metabolism & Lipidology Unit), Faculty of Medicine, Alexandria University, Alexandria, Egypt
Talaat Abdelaaty, Department of Internal Medicine (Diabetes, Metabolism & Lipidology Unit), Faculty of Medicine, Alexandria University, Alexandria, Egypt
Hend Ghallab, Department of Internal Medicine (Diabetes, Metabolism & Lipidology Unit), Faculty of Medicine, Alexandria University, Alexandria, Egypt
Shimaa M. Elrahmany, Department of Internal Medicine (Diabetes, Metabolism & Lipidology Unit), Faculty of Medicine, Alexandria University, Alexandria, EgyptFollow

Subject Area

Internal Medicine

Article Type

Original Study

Abstract

Background The uric acid index (UAI) has recently gained recognition as a potential indicator for cardiovascular risk, particularly among middle-aged individuals. This research investigated the association between UAI levels and cardiovascular disease risk in Egyptian patients with type 2 diabetes (T2DM). Methods 200 individuals with T2DM were included in this cross-sectional analysis. The UAI was derived using the logarithmic formula: Ln [fasting triglycerides × fasting uric acid × fasting glucose ÷ 2]. To estimate the 10-year risk of cardiovascular events, the SCORE2-Diabetes was employed. Results The average serum uric acid level was 4.40 ± 1.48 mg/dL, and the mean UAI was 10.65 ± 0.89. Both uric acid and UAI showed a significant positive correlation with the SCORE2-Diabetes, with UAI demonstrating a stronger association (r = 0.507, p < 0.001). Moreover, the UAI demonstrated a graded increase across the cardiovascular risk categories. Furthermore, the receiver operating characteristic curve demonstrated good discriminative capacity for UAI, with an area under the curve of 0.744 for high-risk and 0.757 for very high-risk patients. Conclusion The UAI serves as a reliable, accessible, and cost-effective biomarker for assessing the probability of developing cardiovascular disease in adults with type 2 diabetes, highlighting its potential for integration into clinical practice.

Recommended Citation

Fathallah, Reem; Abdelaaty, Talaat; Ghallab, Hend; and Elrahmany, Shimaa M. (2025) "ASSOCIATION OF URIC ACID INDEX AND CARDIOVASCULAR RISK IN EGYPTIAN PATIENTS WITH TYPE 2 DIABETES," Mansoura Medical Journal: Vol. 55 : Iss. 1 , Article 11.
Available at: https://doi.org/10.58775/2735-3990.1462