5-HT1A Receptor Gene Polymorphism (C-1019G) in Patients with Primary Premature Ejaculation

Ali Mohamed Ali Mahmoud, Resident of Dermatology, andrology and STDs, Faculty of Medicine, Mansoura University, EgyptFollow
Mohamed Khaled Galal Selim, Professor of Dermatology, andrology and STDs, Faculty of Medicine, Mansoura University, Egypt.
Sherif Refaat Ismael, Lecturer of Dermatology, andrology and STDs, Faculty of Medicine, Mansoura University, Egypt.
Ahmad Shawki Hasan, Assistant Professor of Clinical Pathology, Faculty of Medicine, Mansoura University, Egypt.

Subject Area

Dermatology

Article Type

Original Study

Abstract

Background: Twenty to thirty percent of men experience premature ejaculation (PE). The bioactive amine serotonin (5-hydroxytryptamine, 5-HT) produces a diverse array of outcomes in the brain and other tissues. Researchers investigated serotonin in relation to many other activities and events, including sexual functions. This study set out to investigate whether or not there is a correlation between intravaginal ejaculatory latency time (IELT) with the C-1019G promoter polymorphism (rs6295) in 5-HT1A receptor gene in men who have lifelong PE.

Methods: The current study included 50 cases with PE and 50 apparently healthy subjects as a control group. Participants were assessed for erectile dysfunction and premature ejaculation severity after a comprehensive medical history was obtained, a clinical examination was carried out, and written informed consent was obtained from each participant. The study was approved by the institutional review board at the Mansoura Faculty of Medicine. Conventional polymerase chain reaction (PCR) with restriction fragment length polymorphism (RFLP) technology was used to assess genotypes for 5-HT1A receptor gene variants (C-1019G).

Results: Statistical analysis of the 5-HT1A gene genotyping distribution revealed that the patients group had an eighty-four percent prevalence of the CG genotype, while the control group had a fifty percent prevalence. The cases with CG genotype had the shortest IELT followed by cases with CC genotype. There was high statistically significant difference between the different genotypes regarding the IELT.

Conclusion: The pathophysiology of PE is believed to be linked to the 5-HT1A receptor gene polymorphism (C-1019G). Premature ejaculation and worsening of its symptoms were both shown to be connected with the CG genotype.

Recommended Citation

Mahmoud, Ali Mohamed Ali; Selim, Mohamed Khaled Galal; Ismael, Sherif Refaat; and Hasan, Ahmad Shawki (2026) "5-HT1A Receptor Gene Polymorphism (C-1019G) in Patients with Primary Premature Ejaculation," Mansoura Medical Journal: Vol. 55 : Iss. 3 , Article 13.
Available at: https://doi.org/10.58775/2735-3990.1551