Effect Of Dexmedetomidine Versus Magnesium Sulfate On Intraocular Pressure In Glaucoma Surgery: A Randomized Controlled Trial

Nourhan E. Elhadidi, Resident at Department of Anesthesia and Surgical Intensive Care, Faculty of Medicine, Mansoura University, Mansoura, Egypt .Follow
Nevert A. Abdelghaffar, Professor at Department of Anesthesia and Surgical Intensive Care, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Nabil A. Mageed, Professor at Department of Anesthesia and Surgical Intensive Care, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Amany Tarbay, Lecturer at Department of Anesthesia and Surgical Intensive Care, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Subject Area

Anaesthesia and Surgical Intensive Care

Article Type

Original Study

Abstract

Background : Lowering the intraocular pressure (IOP) is regarded as a primary and initial treatment option for glaucoma. Dexmedetomidine and Magnesium sulfate are known to have intraocular pressure-lowering effects which improve visual fields in patients with primary open angle glaucoma and attenuate intraocular pressure spikes induced by tracheal intubation. Aim: To evaluate and compare the safety and efficacy of using Dexmedetomidine versus Magnesium Sulfate on intraocular pressure and the incidence of postoperative hyphema. Methods : This study included 100 patients both male and female with American Society of Anesthesiologists (ASA) physical status class ɪ and ɪɪ scheduled to undergo elective glaucoma surgery. Ten patients were excluded from the study. Included patients were divided into three groups: group (D) included patients who received only Dexmedetomidine, group (M) included patients who received only Magnesium Sulfate and group (C) included patients who received only normal saline 0.9%. Intraocular pressure was recorded on arrival at preanesthetic room and at the end of drug infusion by Schiøtz tonometer. Results : The highest improvement in IOP was detected among group D followed by group M (40.7% versus 38.5%, respectively) and the least in group C with p=0.001. Conclusion : Both Dexmedetomidine and Magnesium Sulfate have intraocular pressure-lowering effects in glaucoma surgery with more reduction using Dexmedetomidine. Lowest incidence of hyphema was recorded with Magnesium Sulfate followed by Dexmedetomidine.

Recommended Citation

Elhadidi, Nourhan E.; Abdelghaffar, Nevert A.; Mageed, Nabil A.; and Tarbay, Amany (2025) "Effect Of Dexmedetomidine Versus Magnesium Sulfate On Intraocular Pressure In Glaucoma Surgery: A Randomized Controlled Trial," Mansoura Medical Journal: Vol. 55 : Iss. 3 , Article 7.
Available at: https://doi.org/10.58775/2735-3990.1501