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Subject Area

Dermatology

Article Type

Original Study

Abstract

Background: Melasma is a common hyperpigmentation disorder affecting millions worldwide. This study was done to evaluate effectiveness of combined intradermal injections of Tranexamic acid (TxA) and ascorbic acid compared to TxA alone with placebo in managing facial melasma. Methods: This randomized controlled study included twenty patients diagnosed with epidermal melasma were divided into two groups. In Group A, one side of the face received 0.5 ml of TxA (50 mg) with 0.5 ml of normal saline; in Group B, the other side received 0.5 ml of TxA plus 0.5 ml of ascorbic acid. Treatment efficacy was assessed by measuring the modified Melasma Area and Severity Index (mMASI) separately for each facial half during follow-up. Results: Group B exhibited a significantly greater reduction in mMASI scores compared to Group A. Additionally, after three months, telangiectasia was resolved more frequently in Group B. Side effects were reported in 40% of Group A patients but occurred more frequently in Group B (85%). The comparison of mMASI score reductions and improvement degrees strongly favored the combination therapy group. Conclusion: The use of vitamin C with TxA demonstrates superior efficacy compared with TxA alone in treating melasma, resulting in higher improvement rates and decreased mMASI scores.

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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