Survivin and C-reactive protein serum levels in acne vulgaris patients in relation to its severity

Asmaa Ayman Gouda, Resident of Dermatology & Andrology, Faculty of Medicine, Mansoura University, Egypt.Follow
Sara Hamdy Fouad, Lecturer of Dermatology, Faculty of Medicine, Mansoura University, Egypt.
Hyam Sameh Nada, Lecturer of Clinical Pathology (Clinical Chemistry Department), Faculty of Medicine, Mansoura University, Egypt.
Hanan Ahmed Salem, Professor of Dermatology, Faculty of Medicine, Mansoura University, Egypt.

Subject Area

Dermatology

Article Type

Original Study

Abstract

Background: Acne vulgaris (AV) is a chronic inflammatory disease of the pilosebaceous unit with variable clinical severity. Increasing evidence suggests that acne may represent a localized inflammatory condition with potential systemic inflammatory involvement. Survivin, an inhibitor of apoptosis protein has been implicated in abnormal keratinocyte and sebocyte survival, while C-reactive protein (CRP) is a biomarker of systemic inflammation.

Aim of the study: To evaluate serum survivin and CRP levels in cases with AV compared to healthy controls and to assess their relationship with disease severity.

Subjects and methods: This case-control study included 45 patients with clinically diagnosed AV and 45 age- and sex-matched healthy controls. Assessment of AV severity was conducted using the Global Acne Grading System (GAGS). Measurements of serum survivin and CRP levels were taken and compared in both groups, and their correlation with acne severity was analyzed.

Results: Serum survivin and CRP levels were significantly higher in AV cases compared to controls. Both biomarkers showed a statistically significant increase with increasing acne severity as assessed by GAGS score. Survivin demonstrated better performance characteristics than CRP in predicting severe acne.

Conclusion: Elevated serum survivin and CRP levels are accompanied by AV and correlate positively with disease severity. Survivin, in particular, may represent a promising biomarker reflecting disease activity and severity in AV.

Recommended Citation

Gouda, Asmaa Ayman; Fouad, Sara Hamdy; Nada, Hyam Sameh; and Salem, Hanan Ahmed (2026) "Survivin and C-reactive protein serum levels in acne vulgaris patients in relation to its severity," Mansoura Medical Journal: Vol. 55 : Iss. 5 , Article 9.
Available at: https://doi.org/10.58775/2735-3990.1570