Evaluation of Cardiac Troponin T and Ischemia-Modified Albumin Changes with Hemodialysis Session in Pediatric Patients with End-Stage Renal Disease

Zeinab Ezz Elden Abass Abd Eldayem, Department of pediatric, Minyt El Naser Hospital, Egypt.Follow
Ashraf Mohammed Abdel Basset, Department of pediatric, Faculty of Medicine, Mansoura University, Egypt.
Gehan Attia Abdehakem, Department of pediatric, Faculty of Medicine, Mansoura University, Egypt
Shiama Abdelmgiad, Department of pediatric, Faculty of Medicine, Mansoura University, Egypt.
Nermin Yossef Abo Elkheir, Department of clinical pathology, Faculty of Medicine, Mansoura University, Egypt.

Subject Area

Cardiology

Article Type

Original Study

Abstract

Background : Cardiovascular status in dialysis patients is complicated by a wide range of factors that can affect long-term prognosis. Cardiac biomarkers changes with hemodialysis session could affect the cardiac integrity of those patients. Aim of the work: Assess the changes of cardiac ischemic biomarkers (Troponin T and ischemia modified albumin) before and after hemodialysis session in patients with ESRD in pediatric age group and study of correlations of changes with the hemodialysis parameters. Patients and methods: The study included 40 pediatric ESRD patients who were admitted to Pediatric Cardiology Unit, Pediatric Nephrology and Dialysis Unit of Mansoura University Children’s Hospital. All the cases underwent history taking, clinical examination and assessment of basic laboratory data. Body measurements, vital data, echocardiographic findings and Bioimpedance analysis were assessed before and after the dialysis sessions. Measurements of IMA & Troponin T were performed using ELISA commercial kits Results: There was no significant difference regarding heart rate, IMA level or troponin T after dialysis as compared to before dialysis. There were 17 patients (42.5%) with Increase in IMA and Troponin (group 1) and there were 23 patients (57.5%) with No increase in IMA and Troponin (group 2). A significant positive correlation was detected between the rise in IMA & hs-cTnT with ultrafiltration volume. significant positive correlation between diastolic BP change and the rise of hs-cTnT but not with IMA. Conclusion: Support the hypothesis that hemodynamic stress during dialysis may contribute to subclinical myocardial injury in this vulnerable population.

Recommended Citation

Eldayem, Zeinab Ezz Elden Abass Abd; Basset, Ashraf Mohammed Abdel; Abdehakem, Gehan Attia; Abdelmgiad, Shiama; and Elkheir, Nermin Yossef Abo (2026) "Evaluation of Cardiac Troponin T and Ischemia-Modified Albumin Changes with Hemodialysis Session in Pediatric Patients with End-Stage Renal Disease," Mansoura Medical Journal: Vol. 56 : Iss. 1 , Article 10.
Available at: https://doi.org/10.58775/2735-3990.1516