The potential role of Naftidrofuryl oxalate in rat model of ulcerative colitis

Authors

• Omar Mohsen Elmazny, Department of Clinical Pharmacology, Faculty of Medicine, Mansoura University, EgyptFollow
• Ahmed Abdel-monem Elmetwally, Department of Clinical Pharmacology, Faculty of Medicine, Mansoura University, Egypt
• Vivian Boshra, Department of Clinical Pharmacology, Faculty of Medicine, Mansoura University, Egypt
• H.M. El-beltagi, Department of Clinical Pharmacology, Faculty of Medicine, Mansoura University, Egypt
• Basma Hamed Othman, Veterinarian at Mansoura Medical Experimental Research Center MERC, Faculty of Medicine, Mansoura University, Egypt
• Heba Sheta, Department of Anatomic Pathology, Faculty of Medicine, Mansoura University, Egypt

Subject Area

Pharmacology

Article Type

Original Study

Abstract

Background: Ulcerative colitis (UC) is a chronic, recurrent bowel disease characterized by inflammation that leads to superficial damage to the colon wall. The rate of incidence of UC differs from 0.5 to 31.5 per 100,000 subjects annually. The exact cause is still not well-identified. Studies suggest genetic factors, altered immune response, and environmental factors may play a role in the initiation and progression of the disease. Its pharmacological treatment remains unsatisfactory. Aim: To assess the possible protective effect of Naftidrofuryl oxalate (NFT) (praxilene) on intestinal epithelial cells in acetic acid (AA)-induced UC model in rats.  Materials and Methods: sixty female Sprague dewely rats were divided into equal six groups: control, sulfasalazine-treated control, praxilene-treated control, nontreated acetic acid induced UC, sulfasalazine-treated acetic acid induced, and praxilene-treated acetic acid induced UC groups. Disease activity index (DAI), pathological assessment including macroscopic and histopathological, ulcer area/index assessment were evaluated, colonic levels of inflammatory (TNFα-Serotonin), oxidative (MDA-SOD) and apoptotic (caspase 3) biomarkers in tissue homogenate were assessed. Results: Administration of praxilene caused improvement in the DAI scores. Macroscopic assessment, together with histopathological evaluation confirmed near-complete mucosal healing and restoration of colonic architecture. Praxilene significantly exerted antioxidant effect by decreasing colonic level of MDA and enhancing SOD activity, also showed significant anti-inflammatory effect by decreasing colonic levels of TNF-α and serotonin, additionally anti-apoptotic effect by decreasing caspase-3 colonic level.

Conclusion: It can be concluded that praxilene exhibited beneficial effects against acetic acid induced UC. NFT could be considered a promising new agent in the treatment of UC.

Recommended Citation

Elmazny, Omar Mohsen; Elmetwally, Ahmed Abdel-monem; Boshra, Vivian; El-beltagi, H.M.; Othman, Basma Hamed; and Sheta, Heba (2026) "The potential role of Naftidrofuryl oxalate in rat model of ulcerative colitis," Mansoura Medical Journal: Vol. 56 : Iss. 1 , Article 4.
Available at: https://doi.org/10.58775/2735-3990.1586

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