•  
  •  
 

Subject Area

Clinical Pathology

Article Type

Original Study

Abstract

Aim: Hypoalbuminemia is a well-known risk factor for illness and death, but its role as a particular predictor of acute kidney injury (AKI) is still not fully understood. This study intended to evaluate the role of hypoalbuminemia as a predictive factor for AKI outcome among pediatric patients, regarding hospital stay, kidney replacement therapy and mortality rate.

Subjects and Methods: This prospective observational cohort was conducted on 70 children with AKI divided into two groups: group I (35 AKI children combined with hypoalbuminemia) and group II (35 AKI children without hypoalbuminemia). All participants were subjected to full history taking, clinical examination and laboratory investigations. The duration of hospital stay, clinical intervention and mortality were recorded.

Results: Compared to children in group II, those in group I had significantly reduced urine output (p=0.003) and a higher nephropathy grade (p=0.005). Additionally, compared to group II children, group I children had a higher death rate, required more renal replacement treatment (0.02 and 0.024, respectively), and spent more time in the hospital (p=0.001). Following multivariate regression analysis, lower albumin levels and higher INR values continued to be significant predictors for ICU admission (p=0.03 and 0.04, respectively).

Conclusion: hypoalbuminaemia was associated with worse outcome underscoring its prognostic value in the pediatric critical care setting. These findings highlight the importance of early recognition and correction of hypoalbuminemia as part of the comprehensive management strategy for AKI in children.

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Download

Share

COinS