Subject Area
Dermatology
Article Type
Original Study
Abstract
Background: Psoriasis is a persistent, immune-mediated dermatological condition influenced by complex genetic architectures and systemic inflammation. This investigation evaluated the diagnostic utility of serum β2-microglobulin β2 as a quantitative indicator for gauging clinical severity in psoriatic patients.
Aim of the work: The primary objective of this investigation was to evaluate the diagnostic utility of serum β2-microglobulin (β2M) as a quantitative biomarker for assessing disease severity in patients with psoriasis vulgaris. Specifically, the study sought to determine the correlation between circulating β2M levels and established clinical parameters, including the Psoriasis Area and Severity Index (PASI), body mass index (BMI), and disease chronicity to facilitate objective patient stratification and cardiovascular risk monitoring.
Methods: We conducted a case-control analysis involving 30 individuals with the plaque variant of psoriasis vulgaris and 20 healthy controls. Participants were matched for age, gender, and Body Mass Index (BMI). Severity was stratified using the Psoriasis Area and Severity Index (PASI). Circulating β2M concentrations were quantified through a double-antibody sandwich ELISA protocol.
Results: Significant discrepancies were observed between the cohorts regarding systolic/diastolic blood pressure, BMI, and β2M concentrations. Statistical modeling identified robust positive correlations between serum β2M and BMI (r=0.66), disease length (r=0.78), and PASI scores (r=0.73). Furthermore, a moderate positive link was established between PASI ratings and BMI (R=0.57), alongside a significant correlation between severity and the duration of the disease.
Conclusion: The results suggest that β2M serves as a dependable and objective biomarker for assessing the clinical burden of psoriasis. The heightened cardiovascular indicators recorded in this cohort emphasize the necessity for integrated, systemic clinical management in psoriatic patients
Recommended Citation
Shaaban, Ishraq Mazhar; El Dakrory, Fatma Faisal; Elmaksoud, Alshaimaa Hamdi Abd; and Soliman, Youssef El-Bayoumi Youssef
(2026)
"Evaluation of β2-Microglobulin in Patients with psoriasis vulgaris Case Controlled Study,"
Mansoura Medical Journal: Vol. 56
:
Iss.
1
, Article 8.
Available at:
https://doi.org/10.58775/2735-3990.1588
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
