Subject Area
Dermatology
Article Type
Original Study
Abstract
Introduction Atrophic acne scars are challenging to treat, prompting interest in regenerative therapies like platelet-poor plasma (PPP) gel. The purpose of this study is to compare the therapeutic efficacy and safety of manually versus automatically prepared PPP gel for treating atrophic acne scars. Material and Methods In a prospective, randomized, single-blind study, 40 patients with atrophic acne scars were divided into two equal groups. Group 1 received manually prepared PPP gel, and Group 2 received automated PPP gel, both following subcision. Treatment outcomes were evaluated using dermoscopic imaging, Goodman and Baron qualitative grading system, and patient satisfaction scores over a 30-week follow-up. Results Both groups showed significant reductions in fibrous tissue area (~70% improvement), with no statistically significant differences between them. Mild, transient adverse effects were noted, and patient satisfaction was high in both groups. No demographic variables significantly influenced treatment outcomes. Conclusion Manual and automated PPP gels are equally effective, safe, and well-tolerated treatments for atrophic acne scars. PPP gel presents a promising autologous filler, though further large-scale, long-term studies are recommended.
Recommended Citation
Dorgham, Yassmin Gamal Salem; Dakrory, Fatma Faisal El; and Moubarak, Marwa Zohdy Ali
(2025)
"A Comparative Study on the Therapeutic Efficacy of Manual versus Automated Prepared Platelet Poor Plasma Gel for Atrophic Acne Scar Treatment: A prospective Randomized Interventional Study,"
Mansoura Medical Journal: Vol. 56
:
Iss.
2
, Article 1.
Available at:
https://doi.org/10.58775/2735-3990.1445
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This work is licensed under a Creative Commons Attribution 4.0 International License.
