Subject Area
Pathology
Article Type
Original Study
Abstract
Background: High-grade serous ovarian carcinoma (HGSOC) is known for its high recurrence rate and eventually develops platinum resistance. HGSOC has heterogeneity in both histopathology and immunohistochemistry. This heterogeneity made it essential to analyze the relationship of clinicopathological characteristics with platinum response. Furthermore, finding determinants of therapy response and survival remains of tremendous significance for improving patient outcomes.
Methods: This retrospective study, conducted at pathology lab of Oncology Center Mansoura University (OCMU) and pathology department, Faculty of Medicine, Mansoura University included 88 cases of HGSOC classified into platinum-sensitive (n = 64) and platinum-resistant (n = 24) groups. In each group; clinicopathological parameters, histopathological subtypes (mesenchymal, proliferative, immunoreactive, and differentiated subtypes) and immunohistochemical markers (WT1, ER, PR, p53) were analyzed and correlated to platinum response.
Results: Platinum response did not show significant associations between and age, stage, CA125, ascites, lymphovascular invasion, omental deposits, histopathological subtype, or immunohistochemical markers.
Conclusion: Conventional clinicopathological and immunohistochemical markers have no significant association regarding response to platinum based chemotherapy. Molecular profiling should be integrated in personalized treatment plans.
Recommended Citation
Elhadidy, Samar S.; Hany, Heba; Sakr, Doaa H.; Nagib, Reham Mohamed; and Abdelhalim, Wagiha Mohamed
(2026)
"Histopathological and Immunohistochemical Characterization of Platinum Sensitive and Platinum Resistant High Grade Serous Ovarian Carcinoma: A Comparative Study,"
Mansoura Medical Journal: Vol. 56
:
Iss.
3
, Article 3.
Available at:
https://doi.org/10.58775/2735-3990.1620
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
